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Peptide Therapy for Weight Loss

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Dr. Trever Wilkins, DO
Medical Director

We've been taught our whole lives about the importance of fitness and living an active lifestyle. However, this may be more challenging to maintain the older you get. Perhaps you are beginning to recognize a slower metabolism, atypical hormone levels, or possibly even some new aches and pains in your muscles and joints. This can be disappointing and discouraging in regards to your daily activities, sports, and possibly even self esteem. I'm aware that weight loss tends to have a negative stigma surrounding it. However, there are ways to optimize your health through weight management in a healthy and timely fashion. Peptide therapy can help you achieve these weight loss goals.

What are peptides?

Peptides are strings of amino acids that your body makes. They are the building blocks of proteins. Lab-made peptides are used in medicines to help benefit your muscles, skin, and weight management. Peptides are a key factor in the optimization of human performance.

How does peptide therapy work?

Your body creates peptides on its own, but unfortunately, as we age, our bodies slow down. When our bodies slow down, so does the production of proteins and hormones. Administering additional peptides in specific formulas can help these peptides act as hormones, optimizing the targeted areas that we want to improve- including weight loss. Peptides can be consumed topically, in liquid-form, or through injections. To begin seeing results, patients will typically need to come in once a month for six months.

Peptide therapy for weight loss

It is important to remember that genetics, age, activity, diet, and lifestyle all are important factors in weight loss. Peptide therapy is most successful when combined with other lifestyle improvements, including exercise and diet. Having said that, you may be doing all you can with little success in reaching your goals. This is where peptide therapy can accommodate. For example, some peptides boost human growth hormone (HGH) production, which can increase your energy, lean body mass, and recovery from muscle fatigue speed. To understand the peptide therapy we utilize for weight maintenance at Optimize You Performance Medicine, let's take a closer look at each peptide formula.


Semaglutide is a peptide that is created by the gut. It helps regulate blood sugar levels by increasing insulin production and reducing appetite. It works by delaying gastric emptying, which allows the body to better absorb nutrients and helps to control how much sugar is absorbed into the blood. Other potential benefits include:

  • lowered blood sugar
  • promotion of cardiovascular health
  • decreased risk of diabetes
  • signals to your brain that your stomach is "full"
  • suppressed appetite


By age thirty, weight gain can make it harder to see early signs of muscle loss because it can often be masked with fat. Sarcotropin is designed to help people fight the adverse effects of Sarcopenia. This peptide is meant to help people who are struggling with Growth Hormone production. It works by stimulating the pituitary gland, which is responsible for GH production. This increased production can lead to weight loss, increased energy, improved sleep, and a better body composition. However, the drug must be used alongside a healthy diet and lifestyle in order to be effective. Other potential benefits include:

  • improved energy
  • increased lean muscle mass
  • weight loss
  • enhanced cognitive function
  • accelerated healing


Sermorelin is a hormone that helps the brain release more Human Growth Hormone. It is called a "secretagogue" because it stimulates the natural production of a hormone. This results in a more physiological increase in Human Growth Hormone that does not allow for overdosing or lead to resistance of Human Growth Hormone. Sermorelin helps to eliminate fat from the body, boost energy and endurance, and improve the function of the cardiovascular system. It also helps to improve sleep, boost the immune system, and increase muscle mass. It helps with the maintenance and function of the pancreas, as well as boosting the function of the kidneys and improving memory in the brain. Other potential benefits include:

  • lowered blood pressure
  • improvement of the immune system
  • hair re-growth
  • improvement in skin quality
  • increased libido


CJC-1295 and Ipamorelin are peptides that work together to increase growth hormone levels. They work synergistically, which means that they have a greater effect when used together than when used separately. Each peptide targets different receptors in the body, and they work by different mechanisms. Together, they are able to accelerate results. Ipamorelin, by itself, is a peptide that is used in order to help with weight loss, fitness, and overall health and wellness goals. When used in conjunction with other treatments, it can help increase lean muscle and minimize fat storage. It can also help patients who are active see the best results and changes in their body composition. CJC-1295/Ipamorelin is a daily injection that is taken for 12 weeks. It is given 5 days a week with 2 days off. This peptide therapy is known to show changes such as restful sleep after the first 7-14 days and the best changes around month 3. Other potential benefits include:

  • reduced inflammation
  • increased energy
  • promotion of faster healing
  • improved sleep quality
  • increased strength


AOD-9064 is a peptide that helps to break down stored body fat, especially in the abdomen. This can help to reduce inflammation and oxidation in the body. It is a modified form of amino acids 176-191 of the GH polypeptide, and does not seem to affect insulin resistance. This peptide helps to break down body fat. It does this by mimicking the way that natural Growth Hormone regulates fat metabolism. However, unlike Growth Hormone, AOD-9604 does not have any adverse effects on blood sugar or growth. Since AOD-9604 can reduce fat, it has also been used to help prevent the body from developing diseases such as Type 2 Diabetes, cancer, Alzheimer's, dementia, and obesity. Other potential benefits include:

  • prompting of fat release from obese fat cells
  • prevention of fat accumulation
  • boosted metabolism
  • stimulated appetite suppression
  • treatment of bone diseases


Tesofensine is a peptide that prevents serotonin, noradrenaline, and dopamine from being reabsorbed by the central nervous system. This makes people feel less hungry, and so it acts as an appetite suppressant. This peptide also affects the pleasure sensation of food consumption. Tesofensine was originally studied for the treatment of Alzheimer's and Parkinson's, but it was found to not be effective for those conditions. However, people who took the drug in studies consistently reported weight loss, so researchers began studying it for the treatment of obesity instead. Other potential benefits include:

  • weight loss & BMI reduction
  • decreased insulin
  • improved regulation of glucose metabolism
  • improvement in waist and hip circumference
  • decreased body fat

Which weight loss program is best?

Having a plan from a provider is going to be your best solution in figuring out your options and deciding which personalized program is best for you. Not only can a health professional aid in this, but also having an expert present for accountability and tracking metrics is crucial in seeing success from your customized peptide therapy plan. Any of these weight loss peptides can be combined with other pharmaceutical weight loss medicines. A couple of other helpful adjuncts include additional supplements, IV vitamin infusions, and MIC B12 injections. MIC B12 injections contain a blend of nutrients that help your body release fatty deposits. They also stimulate the metabolism and give a boost of energy. Most importantly, if you truly want to see results and reach your weight loss and fitness goals, you will need to be cautious of your lifestyle habits and nutrition.

Trusted Peptide Therapy for Weight Loss Practitioners in The Arizona East Valley

Find peptide therapy that’s best for you with the help of friendly medical professionals. Optimize You hosts some of the best peptide therapy for weight loss practitioners in Arizona.

If you’re curious about peptide therapy, we recommend you book an appointment with our experts. That way, you can gain in-depth knowledge about the practice and feel comfortable with your treatment. Education and knowledge are part of the process toward becoming a healthier you.

*Disclaimer: Please note peptide therapy results may vary. The health results claimed on our site are based on medical studies and also individual results. However, these examples may not be applicable and/or typical to all patients of Optimize You Performance Medicine.

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